Eyal S. Ron, Ph.D.

    MADASH, LLC.
     7 Coach Rd, Suite 100
     Lexington, MA 02420-1101
     T: +1 617-308-8200
     F: +1 208-740-5966
     E: Eyal@MADASH.com

 
Dr. Ron was invited to speak on the process of selection a CRO from a small company perspective during the Outsourcing in Clinical Trials New England 2013 (October 1-2, 2013, Boston, MA). The slides can be viewed here.

Attiva and Gellica, Two Novel Superabsorbent Biodegradable Hydrogels, Decrease Food Intake in Rats. Presented at The Obesity 2010, 28th Annual Scientific Meeting, San Diego, California, October 8?12, 2010.

Attiva, a Novel Superabsorbent Biodegradable Hydrogel, Increases the Feeling of Satiety in Humans. Hassan M. Heshmati, MD, Roberto Tacchino, MD, Eyal S. Ron, PhD, Alessandro Sannino, PhD, and Yishai Zohar. American Association of Clinical Endocrinologists, Boston, MA. April 21-25, 2010.

L-Arginine: A dietary Supplement that Improves Vascular Function by Overcoming the Deleterious Effects of ADMA, a Novel Cardiovascular Risk Factor. Böger, R.H., Ron, E.S. Alternative Medicine Review, 2005, 10(1), 14

Study of the Break Up Under Shear of New Thermally Reversible W/O/W Multiple Emulsion. Olivieri, L.; Seiller, M.; Bromberg, L.; Ron, E.S.; Couvreur, P.; Grossiord, J.L. Pharmaceutical Research, 2001, 5(18), 689

Determination of the Nasal Retention of Smart Hydrogel? Using Gamma Scintigraphy. Jackson, S.J.; Bush, D.; Washington, N.; Ron, E.S.; Schiller, M.; J. of Pharmacy & Pharmacol. (suppl. 4) 1997, 49:84

Temperature-responsive Gels and Thermogelling Polymer Matrices for Protein and Peptide Delivery. Bromberg, L.E.; and Ron, E.S.; Adv. Drug Delivery Reviews, 1998, 31, 197.

In vivo Determination of the Esophageal Retention of Smart Hydrogel?. Potts, A.M.; Jackson, S.; Washington, N.; Gilchrist, P.; Ron, E.S.; Schiller, M.; and Wilson, C.G.; Proc. Intern. Symp. Control. Rel. Bioact. Mater., Controlled Release Society, 24, 1997, pp 335.

Smart Hydrogel?: a Novel Mucosal Delivery System. Ron, E.S.; Bromberg, L.; Luszak, S.; Kearney, M.; Deaver, D.R.; and Schiller, M.; Proc. Intern. Symp. Control. Rel. Bioact. Mater., Controlled Release Society, 24, 1997, pp 407.

Novel Drug Carriers Based on Physical Gels of Pluronic® Polyethers Grafted to Chitosan Backbones: Synthesis and Solution Properties. Hoffman, A.S.; Wu, X.; Ding, Z.; Schiller, M.; Ron, E. Intern. Symp. Control. Rel. Bioact. Mater., Controlled Release Society, 24, 1997, pp 563.

Graft Copolymers of PEO-PPO-PEO Triblock Polymers on Bioadhesive Polymer Backbones: Synthesis and Properties. Hoffman, A. S.; Chen, G.; Wu, X.; Ding, Z.; Kabra, B.; Randeri, K.; Schiller, M.; Ron, E.; Peppas, N.A.; Brazel, C. Polymer Reprints, 1997, 38 (1), 524.

Applications of Poly(acrilic acid)-g-(oxyethylene-b-oxypropylene-b-oxyethylene) Polymers (Smart Hydrogel?) in Drug Delivery. Bromberg, L.E.; Mendum, T. H. E.; Orkisz, M..; Lupton, E. C.; Ron, E. S. Polymer Mater. Sci. Eng., 1997, 76, 273.

Recombinant Human Bone Morphogenetic Protein-2 Stimulates Differentiation in Primary Cultures of Fetal Rat Calvarial Osteoblasts. Chaudhari, A.; Ron, E.; Rethman, M. P. Mol Cell Biochem. 1997, 167, 31.

Interpenetrating Networks of Poloxamer Copolymers and Poly(acrylic acids) as Vehicles in Controlled Drug Delivery. Bromberg, L.; Orkisz, M.; Roos, E.; Ron, E. S.; Schiller, M. Fourth European Symposium on Controlled Drug Delivery. 1996, 126.

Poly(?-hydroxy acid) Carrier for Delivering Recombinant Human bone Morphogenetic Protein-2 for Bone Regeneration. Hollinger, J.; Mayer, M.; Buck, D.; Zegzula, H.; Ron, E.; Smith, J.; Jin, L.; Wozney, J. J. Controlled Rel. Vol. 3, Issue 2-3, 1996, 287-304

Maxillary alveolar cleft repair in dogs using recombinant human bone morphogenetic protein-2 and a polymer carrier. Mayer, M.; Hollinger, J.; Ron, E.; Wozney, J. Plast Reconstr Surg. 1996, 98, 247.

Osseous Regeneration in Preclinical Models Using Bioabsorbable Delivery Technology for Recombinant Bone Morphogentic Protein 2 (rhBMP2). Smith, J. L.; Jin, L.; Parsons, T, Turek, T.; Ron, E.; Philbrook, C. M.; Kenley, R. A.; Marden, L.; Hollinger, J.; Bostrom, M.P.G.; Tomlin, E.; Lane, J. M. J. Controlled Rel. 1995, 36(1-2), 183.

Biodegradable Endoluminal Polymer Layers Provided Sustained Transmural Heparin Delivery to the Arterial Wall in vivo. Slepian, M. J.; Cambell, P. K.; Berrigan, K.; Roth, L.; Massia, S. P.; Weselcouch, E.; Ron, E.; Mathiowitz, E.; Jacob, J.; Chickering, D.; Philbrook, M. Circulation 1994, 90 (4 Part 2), 120.

Novel Delivery Systems for rhBMP-2: Efficacy Determination in Rats and Dog Calvarial Critical-Sized Defects. Kenley, R.; Jin, L.; Ron, E.; Marden, L.; Hollinger, J.O. Orthop. Res. Soc. 1994, 19(2), 504.

Healing of Large Segmental Defects in Rat Femurs is Aided by RhBMP-2 in PLGA Matrix. Lee, S.C.; Shea, M.A.; Battle, M.A.; Kozitza, K.; Turek, T.; Schaus, R.G.; Hayes, W.C.; Ron, E. J. of Biomed. Mat. Res. 1994, 28(10), 1149.

Osseous Regeration in the Rat Calvarium Using Novel Delivery for Recombinant Human Bone Morphogenetic Protein 2 (rhBMP-2). Kenley, R.; Marden, L.; Turek, T.; Jin, L.; Hollinger, J.O.; Ron, E. J. Biomedical Materials Res. 1994, 28(10), 1139.

Recombinant Human Bone Morphogenetic Protein-2 is Superior to Demineralized Bone Matrix in Repairing Craniotomy Defects in Rats. Marden, L.; Hollinger, J.O.; Chaudari, A.; Turek, T.; Schaub, R.G.; Ron, E. J. Biomed. Mat. Res. 1994, 28(10), 1127.

Biotechnology and Bone Graft Substitutes. Kenley, R.A.; Yim, K,; Abrans, J.; Turek, T.; Marden, L.J.; Hollinger, J.O.; Ron, E. Pharm. Res. 1993, 10(10), 1393.

Controlled Release of Polypeptides from Polyanhydrides. Ron, E.; Turek, T.; Mathiowitz, E.; Chasin, M.; Hageman, M.; Langer, R. PNAS 1993, 90, 4176.

The Ability of Recombinant Human Bone Morphogenetic Protein to Heal Segmental Bone Defects. Cole, B.J.; Yasko, A.; Browne, M.G.; Tomin, E.; Waller, S.; Ron, E.; Turek, T.; Schub, R.; Lane, J.M. American Society for Bone and Mineral Research 1992 (in press)

Bioerodible Devices for Bone Morphogenetic Protein (rhBMP-2). Ron, E.; Turek,T.; Schaub, R.; Kozitza, K.; Yasko, A.; Lane, Polymer Materials Science and Engineering 1992, 66, 89.

Physiologic and Synthetic Carriers for Recombinant Human BMP-2. Ron, E.; Yasko, A.W.; Fellinger, E.J.; Tomin, M.; Wang, L.; Lane, J.M. Transaction of the 38th Annual Meeting Orthopedic Research Society February 17 - 20, 1992, 71.

Biologic and Synthetic Matrix Carriers for Recombinant Human BMP-2: Orthotopic Osteoinduction. Yasko, A.W.; Lane, J.M.; Waller, S.; Fellinger, E.J.; Tomin, M.; Wang, E.A.; Ron, E. J. of Bone and Mineral Research 1991, 6, 155.

Erodible Systems. Ron, E. and Langer, R. In Treatise on Controlled Drug Delivery, Kydonieus, A. Ed. Marcel Dekker, Inc. N.Y., 1991, pp. 199 - 224.

NMR Characterization of Erodible Copolymers. Ron, E.; Mathiowitz, E.; Mathiowitz, G.; Langer, R. Macromolecules 1990, 24, 2278.

Hydrolytically Degradable Amino Acid Containing Polymers. Staubli, A.; Ron, E.; Langer, R. J. Am. Chem. Soc. 1990, 112, 4419.

Morphological Characterization of Bioerodible Polymers I. Crystallinity of Polyanhydride Copolymers. Mathiowitz, E.; Ron, E.; Mathiowitz, G.; Amato, C.; Langer, R. Macromolecules 1990, 23, 3212.

Polyanhydrides IV. Unsaturated and Cross-Linked Polyanhydrides. Domb, A. J.; Ron, E.; Mathiowitz, E.; Giannos, S.; Langer, R. J. Polym. Sci. 1991, 29, 571.

Polyanhydrides. Leong, K.; Ron, E.; Domb, A.; Langer, R. In Encyclopedia of Polymer Science, Supplement Volume, 2nd Edition. 1990, pp. 648 - 665.

Polyanhydrides as Drug Delivery Systems. Chasin, M.; Domb, A.; Ron, E.; Mathiowitz, E.; Leong, K.; Laurencin, C.; Brem, H.; Grossman, B.; Langer, R. In Biodegradable polymers as Drug Delivery Systems. Langer, R. and Chasin, M. Editors. Marcel Dekker, Inc. N.Y. 1990, pp. 43 - 70.

Release of Polypeptides from Polyanhydrides Implants. Ron, E.; Turek, T.; Mathiowitz, E.; Chasin, M.; Hageman, M.; Langer, R. AIChE 2nd Topical Conference on Emerging Technologies in Materials, San Francisco, CA. 1989, pp. 91

Polypeptides Release from Polyanhydride implants. Ron, E.; Turek, T.; Mathiowitz, E.; Chasin, M.; Langer, R. Proceedings of the 16th International Symposium on Controlled Release of Bioactive Materials. August 6-9, 1989, Chicago, IL.

Synthesis and Characterization of Poly(amid-co-anhydrides). Staubli, A.; Ron, E.; Langer, R. Polymer Preprints, 1989, 30, 451

Surface Morphology of Biodegradable Polyanhydrides. Mathiowitz, E.; Ron, E.; Mathiowitz, G.; Amato, C.; Langer, R. Polymer Preprints, 1989, 30, 460

A Novel Computerized Approach to Predict Degradation Rates of New Biodegradable copolymers. Ron, E.; Mathiowitz, E.; Mathiowitz, G.; Langer, R. Polymer Preprints, 1989, 30, 462

Copolymer Composition and Microstructure of Polyanhydrides. Ron, E.; Mathiowitz, E.; Mathiowitz, G.; Doh, L.; Amato, C.; Langer, R. Proceedings of the 15th International Symposium on Controlled Release of Bioactive Materials. August 15-19, 1988, Basel, Switzerland

Polyanhydrides II. One Step Polymerization Using Phosgene or Diphosgene as Coupling Agents. Domb, J. A.; Ron, E.; Langer, R. Macromolecules 1988, 21, 1925

New Polyanhydrides: Aliphatic - Aromatic Homoploymers and Unsaturated Polymers. Domb, J. A.; Ron, E.; Kothari, R.; Giannos, S.; Flores, C.; Kim, R.; Doh, L.; Langer, R. Proceedings of the 14th International Symposium on Controlled Release of Bioactive Materials. August 2-5, 1987, pp. 138, Toronto, Canada

Type II intramolecular [2 + 2] Cycloaddition of Alkenes with Vinylketenes Prepared by Regiosepecific Deprotonation of 8,8-Disubstituted a,8-Unsaturated Acid Chlorides. Snider, B. B.; Ron, E.; Burbaum, B. W. J. Org. Chem. 1987, 52, 5413

Synthesis of Terpenes Containing the Bicyclo[3.1.1]heptane Ring System by the Intramolecular [2 + 2] Cycloaddition Reaction of Vinylketenes with Alkenes. Preparations of Chrysanthenone, 8-Pinene, 8-cis-Bergamotene, 8-trans-Bergamotene, 8-Copane, and 8-Ylangene and Lamnalol. Kulkarni, Y. S.; Niwa, M.; Ron, E.; Snider, B. B. J. Org. Chem. 1987, 52, 1568

Lewis Acid Catalyzed Inter- and Intramolecular [2 + 2] Cycloadditions of Conjugated Allenic Esters to Alkenes. Snider, B. B.; Ron, E. J. Org. Chem. 1986, 51, 3643

The Mechanism of Lewis Acid Catalyzed Ene Reactions. Snider B. B.; Ron, E. J. Am. Chem. Soc. 1985, 107, 8016